Research and development in cognitive impairment and dementia

Cognitive impairment and dementia is a hallmark of many diseases, such as Alzheimer’s disease and Parkinson’s disease, that cause a long term and often gradual decrease in mental ability. There is currently no cure for cognitive impairment or dementia and it a major unmet medical need.

 

Additional information on primate cognition models

Cognitive Impairment and Dementia Models

  • Normal young adult macaque
  • Ketamine-treated young adult macaques
  • Scopolamine-treated young adult macaques
  • Normal aged macaques (20 – 25 years old)
  • Chronic low-dose MPTP-treated macaques

Cognitive Tests

  • Paired Associative Learning (PAL)
  • Delayed Matching to Sample (DMTS)
  • Five-choice Serial reaction Time (5-CSRT)
  • Variable Delayed Response (VDR)
  • Attentional Set Shifting/Intra-Extra Dimensional shift (ID/ED)
  • Continuous Performance Task (CPT)
  • Object retrieval task