Model Type: Primate cognition

  • AAV α-synuclein overexpressing non-human primate

    Model Overview AAV1/2-A53T-α-synuclein vectors are injected bilaterally into the substantia nigra of macaques using MRI-based stereotactic techniques. Four injection sites per hemisphere are used to ensure complete viral coverage of the substantia nigra. Degeneration of dopaminergic neurons occurs over several weeks allowing test compounds to be evaluated for disease modifying potential. Some implementations of the…

  • Cognition

    Available models Non-human primate CANTAB Object retrieval in non-human primates The object retrieval task (OR) in non-human primates assesses attention, response inhibition (impulsivity) and planning (frontal/frontostriatal functioning). Chronic low-dose MPTP treatment induces cognitive deficits in non-human primates In this example, CLD-MPTP treatment induces deficits on the CANTAB VDR task that assesses aspects of attention and…