Model Type: Rodent

  • Bilateral 6-OHDA-lesioned rat

    Model Overview Rats or mice, receive bilateral injections of 6-OHDA directly into the striatum resulting in ‘partial’ loss of dopaminergic innervation and subsequent abnormal motor behaviours. Motor deficits can be quantified using the Open-Field Arena and dosedependently reversed via administration of L-DOPA. The bilateral 6-OHDA lesioned rodent is therefore an ideal model in which to…

  • MPTP-lesioned mouse

    Model Overview Various iterations of the MPTP-lesioned mouse are offered by Atuka. In our most commonly used model, MPTP (25 mg/kg, i.p.) is administered to C57bl/6 mice once daily for 5 days. This leads to a loss of tyrosine hydroxylase positive neurons in the substantia nigra that is stable over a period of weeks. Test…