The world’s best preclinical neuroscience
For more than 30 years, in collaboration with some of the best partners in the world, Atuka’s scientists have continued to advance both knowledge and research techniques in the field of Parkinson’s disease and beyond.
BEHIND THE SCIENCE
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Expanding Frontiers in Neuroimmunology
Jon Brotchie reports back with highlights from the recent Neuroimmunology Drug Development Summit in Boston, in particular how TREM2 is emerging as one of the most promising new targets for Parkinson’s, both in terms of mechanism and the variety of approaches we have to potentially manipulate it.
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How AI could help dramatically change the drug discovery process
The upside of integrating AI into the drug discovery process is potentially game-changing, though it’s also important to be clear-eyed and not get too caught up in the hype. Jon Brotchie reflects on AI’s potential benefits in drug development for Parkinson’s, from finding new and better molecules for novel un-imagined…
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Parkinson’s disease prevalence is soaring—but is there a good news story hidden in the data?
As Parkinson’s becomes the fastest-growing neurological disorder worldwide, its rising prevalence raises urgent questions about public health and economic impact. Could improved diagnosis, treatment, and life expectancy offer a hidden silver lining within the statistics?
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Highlights from Neuroscience 2024
At the annual summit of the Society for Neuroscience in Chicago, it was clearer than ever that collaboration and advancing technologies are central to moving the field forward.
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New frontiers in inflammasome therapeutics
Insights from Atuka’s recent visit to the 6th Annual Inflammasome Summit in Boston.
DISCOVERY SERIES

#1 – D1 PAM
Read the first entry in our new series on the latest research on emerging targets in Parkinson’s Disease
The Potential of D1 Dopamine Receptor Positive Allosteric Modulators
WHITE PAPER

Optimizing Preclinical Studies for Parkinson’s Disease Therapeutics
Strategies to optimize preclinical study design for therapeutic development and reduce translational risk.
WHITE PAPER

The future of gene therapy from a pre-clinical perspective
The potential of gene therapies is finally being realized and these therapies can deliver life-changing treatments for a broad range of disorders.
Atuka’s Chief Innovation Officer Dr Patrick A. Howson explores the past, present, and future of gene therapy.
Published papers
Atuka’s scientists have been publishing groundbreaking neuroscience research for many decades, often in collaboration with other renowned leaders in our field. The peer-reviewed papers collected below track the evolution of both our ongoing research and the field more broadly.
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New insights into the organization of the basal ganglia
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Serotonin and Parkinson’s disease: On movement, mood, and madness
/ 136 Citations -
Mechanisms compensating for dopamine loss in early Parkinson disease
/ 72 Citations -
/ 36 Citations -
/ 36 Citations -
/ 35 Citations -
Non-dopaminergic treatments in development for Parkinson’s disease
/ 93 Citations -
/ 31 Citations -
Dietary resveratrol administration increases MnSOD expression and activity in mouse brain
/ 93 Citations -
Striatal histone modifications in models of levodopa‐induced dyskinesia
/ 82 Citations -
/ 61 Citations -
/ 7 Citations -
/ 79 Citations -
/ 32 Citations -
/ 67 Citations -
/ 360 Citations -
Striatal delta opioid receptor binding in experimental models of Parkinson’s disease and dyskinesia
/ 19 Citations -
/ 12 Citations -
Novel pharmacological targets for the treatment of Parkinson’s disease
/ 230 Citations -
/ 10 Citations
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